Women Exposed to DES in Utero Have Elevated Risk of Clear-Cell Adenocarcinoma

Narrative-Cat-Batch2hero_Surveillance_1060x597-2

Hannah K. Weir, an epidemiologist with the CDC, summarizes her study published in Springer Link.

Purpose

Women exposed to diethylstilbestrol (DES) in utero were at elevated risk of clear-cell adenocarcinoma of the vagina and cervix (CCA) as young women. Previous research suggested that this elevated risk of CCA may persist into adulthood. We extended a published analysis to measure CCA risk as these women aged.

Methods

Standardized incidence ratios (SIR) compared CCA risk among women born from 1947 through 1971 (the DES-era) to CCA risk among the comparison group of women born prior to 1947, using registry data that covered the U.S. population.

Results

Incidence rates of CCA among both cohorts increased with age. Among the DES-era birth cohort, higher rates of CCA were observed across all age groups except 55-59 years. SIR estimates had wide confidence intervals that often included the null value.

Conclusions

Results are consistent with prior research and suggest an elevated risk of CCA in midlife and at older ages among women exposed in utero to DES. These results highlight unresolved issues regarding cancer risk among aging DES daughters and appropriate screening guidance. The examination of population-based cancer surveillance data may be a useful tool for monitoring trends in the incidence of other rare cancers over time among specific birth cohorts.

View the study about DES and clear-cell adenocarcinoma of the vagina and cervix among young women who were exposed in utero.

What to Read Next

CiNA Statistics and CiNA*Explorer Update

In June 2024, the 2017-2021 CiNA cancer statistics were updated in CiNA*Explorer: https://apps.naaccr.org/explorer. This update reflects the final migration from…

NAACCR Board of Directors Spearheads Review of NAACCR Certification Standards

Since 1998, NAACCR has evaluated annual data submissions from central cancer registries as part of the NAACCR certification process. Over…

NAACCR Participates in the USCDI+ Cancer Research Data Exchange Summit

On May 8th and 9th, the U.S. Office of the National Coordinator for Health Information Technology (ONC) and other federal…